Autism, autoimmunity and the environment Keely Ruth Cheslack-Postava

ISBN: 9780549936565

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234 pages


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Autism, autoimmunity and the environment  by  Keely Ruth Cheslack-Postava

Autism, autoimmunity and the environment by Keely Ruth Cheslack-Postava
| NOOKstudy eTextbook | PDF, EPUB, FB2, DjVu, audiobook, mp3, RTF | 234 pages | ISBN: 9780549936565 | 5.26 Mb

Autism spectrum disorders (ASD) affect one in 150 children in the United States, and are believed to arise through a complex interplay of genetic and environmental factors. The work described here is an investigation of two components of the fetalMoreAutism spectrum disorders (ASD) affect one in 150 children in the United States, and are believed to arise through a complex interplay of genetic and environmental factors. The work described here is an investigation of two components of the fetal environment---IgG antibodies, and ambient environmental pollutants.-The papers included herein describe a population-based case-control study, including cases of ASD, idiopathic MR and birth certificate controls, born in Californias Central Valley.

IgG antibodies to nervous system and thyroid proteins were measured in archived neonatal heel-stick samples using a multiplex microbead suspension array. No significant increases in risk for ASD, overall or among subjects with mental retardation only, were observed in association with higher levels of nervous system antibodies among the study population as a whole. Decreased odds ratios for ASD were observed, with the strongest evidence for negative association appearing for GFAP and MBP.

These associations were observed after adjusting for a range of potential confounders.-The second component of the study involved linking existing environmental data on an array of pollutants with the autoantibody data assayed in Part 1.

This allowed examination of potential interactions between these two types of exposure. ASD cases and birth certificate controls were linked to estimates for ambient levels of hazardous air pollutants from the EPAs National Air Toxics Assessment, and measures of pesticide applications in proximity to maternal residence using data from Californias Pesticide Use Reports. Association of pollutants with ASD, association of pollutants with antibodies, and effect modification of antibodies by pollutants were then explored using logistic regression models.

Associations observed included ASD and organochlorine pesticide application near maternal residence- and chlorinated solvents and organochlorine pesticides with higher levels of thyroid antibodies. Additionally, significant decreases in odds of ASD were associated with higher nervous system antibody levels among the subjects with lower estimated exposure to pollutants including chlorinated solvents, trichloroethylene and diesel particulate matter, but not among those with higher estimated exposures.-These studies suggest that associations between autism and immunological factors may be present at birth and that chemical exposures may modify such relationships- however, full understanding will require further study.



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